ABO blood groups and Helicobacter pylori cagA infection: evidence of an association
2010
Mattos, DE(São Paulo State University School of Pharmaceutical Sciences Clinical Analysis Department) | Cintra, JR(Regional Medical School Foundation Regional Blood Center of São José do Rio Preto) | Mattos, CC Brandão de(São José do Rio Preto Medical School Molecular Biology Department Immunogenetics Laboratory) | Nakashima, F(São Paulo State University Letters and Exact Sciences Institute of Biosciences) | Silva, RCMA(FUNFARME Base Hospital Specialized Gastroenterology Laboratory) | Moreira, HW(São Paulo State University School of Pharmaceutical Sciences Clinical Analysis Department) | de Mattos, LC(Regional Medical School Foundation Regional Blood Center of São José do Rio Preto ,São José do Rio Preto Medical School Molecular Biology Department Immunogenetics Laboratory)
Diseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.
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