Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation
2010
Carvalho, FR(Butantan Institute Laboratory of Biochemistry and Biophysics) | Vassão, RC(Butantan Institute Laboratory of Cell Biology) | Nicoletti, MA(University of São Paulo Department of Pharmacy) | Maria, DA(Butantan Institute Laboratory of Biochemistry and Biophysics)
The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.
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