Histopathological and histochemical study of free iron as an endogenous chemical mediator of inflammation in chicken
2009
Kumar, M. | Singh, K. K. | Singh, D.D | Gupta, M.K.
The present study places on record the role of free iron as an endogenous chemical mediator of inflammation in chicken. Histopathological and histochemical changes induced by ferrous sulphate alone showed classical inflammatory changes characterised by vacuolar to necrotic changes in epidermal and dermal tissues, interstitial edema and sequential appearance of blood leucocytes ie. heterophils, monocytes, macrophages, epithelioid cells, giant cells and fibroblast cells in perivascular spaces at the site of inflammation at different post induction periods of observation. The lesions induced by EDTA and ascorbic acid treated ferrous sulphate in skin failed to show emigration as well as infiltration of leucocytes from the blood vessels, although vascular and oedematous changes were comparable to ferrous sulphate alone.
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