Effects of Human Milk Fortifier on Growth and Nutritional Status of Growing Rats Fed Infant Formula
2011
Lee, M.R., Seoul National University, Seoul, Republic of Korea | Park, M.N., Seoul National University, Seoul, Republic of Korea | Cho, S.J., Seoul National University, Seoul, Republic of Korea | Jeon, J.W., RnD Center, Maeil Dairies Co. Ltd., Pyungtaek, Republic of Korea | Choi, Y.Y., RnD Center, Maeil Dairies Co. Ltd., Pyungtaek, Republic of Korea | Park, J.S., RnD Center, Maeil Dairies Co. Ltd., Pyungtaek, Republic of Korea | Kim, W.S., RnD Center, Maeil Dairies Co. Ltd., Pyungtaek, Republic of Korea | Lee, Y.S., Seoul National University, Seoul, Republic of Korea
This study was conducted to evaluate the efficacy of human milk fortifier (HMF) on growth and nutritional status in growing rats fed infant formula supplemented with HMF. Three week-old male Sprague-Dawley rats were divided into three groups and fed regular formula (RF), premature formula (PF) and regular formula fortified with HMF (RF＋HMF) diets for 3 weeks. There was no significant difference in weight gain among groups. However, a significant increase of food intake was observed in PF and RF＋HMF groups compared with RF group. With increasing food intake, the intakes of carbohydrate and protein were significantly increased in PF and RF＋HMF groups. The weight of perirenal fat was significantly increased in rats fed RF＋HMF; however, the weights of liver, kidney and spleen were not significantly different among groups. Although total lipids, total cholesterol, HDL-cholesterol concentrations of serum were not significantly different among groups, triglyceride was significantly increased in PF group. The triglyceride and total-cholesterol of liver were significantly increased in rats fed regular formula fortified with HMF and PF compared with RF group. Glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), creatinine (Cre) and blood urea nitrogen (BUN) in serum showed no significant difference among groups. The concentration of growth hormone was significantly increased in PF group compared with other groups. The concentration of hemoglobin was significantly increased in rats fed PF and RF＋HMF. These results suggest that the supplementation of human milk fortifier in growing rats may promote growth as increasing food intake and lipid contents in tissues and prevent the anemia of infants.
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