Immune Regulating Effect of Polysaccharide Fraction from Sea Hare (Aplysia kurodai)
2011
Park, S.H., Gyeongsang National University, Tongyeong, Republic of Korea | Choung, S.Y., Kyung Hee University, Seoul, Republic of Korea | Choi, Y.J., Gyeongsang National University, Tongyeong, Republic of Korea
We extracted polysaccharide from the sea hare, Aplysia kurodai, purified it partially, and experimented its immune response using the human blood lymphocytes and macrophage cell lines. Aplysia kurodai polysaccharide fraction (APF) improved the growth of the T cell (Jurkat) up to 40% by treatment for 48 hours, and decreased the growth of blood cancer, Jiyoye cell line. The APF on RAW 264.7 cell also increased interleukin-12 up to 47%. In contrast, the secretion of interleukin-2 and interferon-gamma by treatment of only APF or APF and concanavalin A on Jurkat for 24 hours and 48 hours didn't influence significantly. These results suggest that the APF has possible immune regulating ability.
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