Mechanisms of cellular protein catabolism.
1982
Mortimore Glenn E.
The synthesis and breakdown of cytoplasmic proteins are essential to protein turnover. Intracellular protein can be classified according to average rates of degradation. The breakdown of short-lived components is thought to be mediated by non-lysosomal mechanisms, and long-lived proteins mediated by lysosomal processes. Perfusion experiments with liver tissue reveal that increased protein degradation in response to insulin and amino acid deprivation is caused by autophagy. Some evidence suggests that protein degradation in the absence of deprivation may occur as a result of microautophagy, a less conspicuous form of autophagy. Influences on primary structure or native conformation of intracellular proteins may prove to be important determinants in the turnover of some proteins. (ds).
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