Kan suksa thang chemi lae rit tang phesat wittaya khong dokpip.
1989
Kalaya Anulakanapakorn | Jutamaad Satayavivad | Nuntavan Bunyapraphatsara
Millingtonia hortensis Linn. f. is an ornamental plant cultivated throughout the country. The dried flowers are not only used for cigarette flavor, they can be used as a remedy for asthma. The attempt to isolate the active constituents was carried out by using pharmacological testing as a tracing tool. Since the methanol extract exhibited the bronchodilating effect on isolated rat's trachea, this extract was further fractionated into petroleum ether, chloroform, N-butanol and aqueous fractions. Pharmacological study indicated that the chloroform fraction elicited the most prominent effect. Further separation of chloroform fraction by short column chromatography, hispidulin, the bronchodilating agent was isolated. Detection by TLC indicated that hispidulin is the one of the compounds present in the smoke of the dried flowers. Therefore it is likely that the antiasthmatic activity of the dried flowers of Millingtonia hortensis Linn. f. is due to hispidulin. Hispidulin is more potent than aminophylline on the equal weight basis. To assure the safety of the patients, the attempts to study the toxic effects of the crude extracts and hispidulin have been made. The studies indicated that hispidulin was less toxic than the crude extract.
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