Effects of histamine, 5-hydroxytryptamine and their antagonists on the uterine motility in the rat.
1988
Yoo K.Y.
This study has been carried out to investigate the augmenting or inhibiting effects of histamine, 5-hydroxytryptamine and their antagonists on the uterine motility. The uterine motility was represented by the magnitude of impulse and the frequency of uterine contraction which was counted by the number of waves on the recording paper. The inhibitory effect of phenoxybenzamine on the response to 5-hydroxytryptamine is the result of drug antagonism. Histamine stimlates or inhibits the motility of smooth muscle through H1 or H2-receptor. The uterine motility was increased through H1-receptor. Histamine induced relaxation by acting through H2-receptor.
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