Experimental trichothecene (T-2) toxicosis in Korean native goats.
1988
Kim J.S.
To investigate the effects of T-2 toxin on the blastogenesis of lymphocytes, pathology, hemogram and blood chemistry in the goat, the Korean native goats were treated orally with T-2 toxin for 21 days with a dosage of 0.6mg per kg body weight. The total count of leukocytes and lymphocytes decreased significantly from 14 to 21 days after treatment. Myeloid : erythroid ratios increased significantly on days 12 after treatment Delayed-type hypersensitivity skin reactions to tuberculin were reduced predominantly. T-2 toxin induced prolonged prothrombin time. Mitogenic responses of lymphocytes to both lipopolysaccharide and phytohemagglutinin were significantly depressed on days 7 and 14 after treatment. Treatment of T-2 toxin caused marked depletion of lymphocytes in the thymus, mesenteric lymph node, Peyer's patches and spleen.
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