Role of SLC11A1 gene in disease resistance
2012
Thomas, N., College of Veterinary and Animal Sciences, Mannuthy, Kerala (India). Centre for Advanced Studies in Animal Genetics and Breeding | Joseph, S., College of Veterinary and Animal Sciences, Mannuthy, Kerala (India). Department of Veterinary Microbiology
Genetic improvement in livestock was achieved earlier by selective breeding of individuals with superior phenotypes. Now due to the advances in molecular genetics and biotechnology candidate genes of economic traits can be included in selection for breeding programmes. Genes responsible for the resistance/susceptibility to infections with various pathogens (Major Histo Compatibility (MHC) genes, Solute Carrier family11 member A1 (SLC11A1) gene, Toll Like Receptor (TLR) genes etc.), have been recently identified and characterized in human beings as well as in many animals . Among these the role of SLC11A1 gene is very important due to its association with resistance/ susceptibility to various intracellular pathogens in human as well as in livestock species. The SLC11A1 gene, formerly known as natural resistance-associated macrophage protein 1 (NRAMP1) encodes an integral membrane protein regulating the activity of macrophages. Genetic resistance/ susceptibility to diseases due to candidate gene polymorphisms could be used in selection and breeding for disease resistance in animals.
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