Integrated bioprocess simulation
2011
Žerajić, S., Faculty of Technology, Leskovac (Serbia)
In this paper, the bioprocess was simulated simultaneously with designing software applications. Integration level may be enhanced with decreasing of a number used program packages. The complex bioprocess was decomposed to the object level by combination of the operational, transformational, and objection access. This development dynamics of the engineering program packages directly incorporated in software applications. Program components were generated with MathCAD program package. The new generating program components were integrated in MathConnex environment. As a case study ethanol fermentation with free and immobilized cells Saccharomyces cerevisiae were simulated. The complete plant model was then used to perform supply optimization, in which alternatives were evaluated. Several strategies were examined to find the best feed for the plant considering issues such as feed cost, product quality, and current product value in the market, and to analyze the operation of the plant to identify the optimum conditions under which to operate the plant. The obtained examples demonstrated there is a growth in the application of simulation as part of plant management. To perform on-line simulation the simulator needs to be interfaced to the plant to receive and transmit data.
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