In vitro Antibiotic Bustle of Coral Reef Associated Gastropod, Drupa margariticola (Broderip, 1832) of Tuticorin Coastal Waters, Southeastern India
2009
J.K.P. Edward | T.P. Anand | S. Jonesh | R.S. Sreenivasan | C. Chellaram
To test the antibacterial effect of the extracts of Drupa margariticola obtained using low to high polar solvents, like ethyl acetate, dichloromethane, acetone and methanol. Partial purification of the active crude extract was carried out using column chromatography employing a step gradient solvent system. A maximum inhibition of 7 mm against E. coli was shown by the 100% acetone column purified fractions of D. margariticola at a concentration of 0.125 mg. Minimum Inhibitory Concentration values were found to be lower for the 100% acetone fraction for pathogens, E. coli (0.05 mg), Klebsiella pnuemoniae (0.05 mg), Pseudomonas aerogenosa (0.07 mg) and Streptococcus pnuemoniae (0.07 mg). Thus 100% acetonated fraction of the extract of D. margariticola was considered as potent antibacterial compounds against some human pathogens. The antibacterial potential of the mollusc, Drupa maragariticola becomes a corner stone for the future development of novel biologically active compounds.
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