New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

Shang-Kwei Wang; Chang-Yih Duh

New Cytotoxic Cembranolides from the Soft Coral Lobophytum michaelae

2012

Shang-Kwei Wang | Chang-Yih Duh

Six new cembranolides, michaolides L–Q (1–6), and a known cembranolide, lobomichaolide (7) were isolated from the CH2Cl2 extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1–7 and their cytotoxicity against selected cell lines were evaluated.

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