<i>Vibrio vulnificus</i> septicemia and necrotizing fasciitis in the patients with liver cirrhosis and diabetes mellitus
2012
Miyuki Isonishi | Hiroko Nawata | Shojiro Kato | Masaki Fujita | Akane Shibayama | Hiroyuki Ito | Shinichi Antoku | Mariko Abe
<i>Vibrio vulnificus</i> (<i>V. vulnificus</i>) infection is a rare disease in Japan but the leading cause of death related to raw seafood consumption. We hereby reported a successfully treated case of <i>V. vulnificus</i> septicemia, severe necrotizing fasciitis, disseminated intravascular coagulation and multiple organ failure after raw perch consumption with underlying alcoholic liver cirrhosis and diabetes mellitus. It is the first report of a case of <i>V. vulnificus</i>infection caused by eating raw perch, whereas <i>V. vulnificus</i> infection should be suspected in all of middle-aged to elderly men with underlying immunosuppressive diseases, who have recent consumption of raw seafood or contact with seawater, especially in the summer. The levels of HbA1c and glycoalbumin were not high in the present case, however, obvious hyperglycemia was found even after the infection had completely healed. On reviewing 166 case of <i>V. vulnificus</i> infection in Japan including ours, the complication of diabetes mellitus, one of immunocompromised condition, was found only in 11%, although it had been reported that individuals strongly suspected of having diabetes were 17.2% among the Japanese male population aged from 40 to 74 years. Because diabetes mellitus might be underdiagnosed in the previous reports, intensive examinations are considered to be necessary in order to correctly diagnose diabetes mellitus in patients with severe <i>V. vulnificus</i> infection.
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