PDLLA enriched with ulvan particles as a novel 3D porous scaffold targeted for
2012
Alves, A. | Duarte, Ana Rita C. | Mano, J. F. | Sousa, R. A. | Reis, R. L.
A marine derived polysaccharide, ulvan, extracted from green algae, was combined with poly-d, llacticacid (PDLLA) in order to produce a novel scaffold for bone tissue engineering applications. Threedimensional (3D) scaffolds of PDLLA loaded with ulvan particles were originally prepared by subcriticalfluid sintering with carbon dioxide at 40 ◦C and 50 bar. Prepared matrixes were characterized inorder to validate their suitability to be used as scaffolds for bone tissue regeneration. Characterizationincluded micro-computed tomography, mechanical compression testing, water uptake and degradationtesting, and cytotoxicity assays. In addition, ulvan particles loaded with dexamethasone, were also dispersedwithin the PDLLA matrix and the respective release profile from the samples was evaluated.Prepared PDLLA scaffolds enriched with ulvan particles demonstrated appropriate physicochemical andcytocompatible features to be used for the envisaged applications. On the other hand, the release ofdexamethasone from ulvan particles embedded within the PDLLA matrix revealed that the designedsystems can be potentially suitable for localized drug delivery. These results further contribute to theestablishment of ulvan as a potential novel biomaterial.
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