Production of a monoclonal antibody by ascites, hollow fiber system, and transgenic plants for vaccine production using CB.Hep-1 mAb as a study case
2012
Valdes, Rodolfo, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Tamayo, Andres, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Gonzalez, Marcos, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Padilla, Sigifredo, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Geada, Deborah, Institute of Tobacco Research, Havana, Cuba | Ferro, William, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Mila, Lorely, Quality Assurance Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Gomez, Leonardo, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Aleman, Rosario, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Leyva, Alberto, Process Control Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Garcia, Cristina, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Mendoza, Otto, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Alvarez, Tatiana, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Dorta, Lamay, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Villega, Yanet, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Cecilia, Dobian, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Aragon, Hasel, Monoclonal Antibody Production Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Gonzalez, Tatiana, Process Control Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba | La O, Maylin, Quality Control Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba | Lopez, Jorge, Quality Control Direction, Center for Genetic Engineering and Biotechnology, Havana, Cuba
Monoclonal antibody (mAb) production methods (ascites, in vitro technologies, transgenic animals, and dicot or monocot transgenic plants; moss, algae) have been improved since they were first developed in 1975. In this study, we illustrate a summary of a study case in which mice, a hollow fiber system, and tobacco transgenic plants were assessed for the production of mAb for vaccine manufacturing and vaccine production.
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