Antioxidant activity of cyanidins isolated from Ogapy (Acanthopanax divaricatus var. albeofructus) fruits in U937 macrophages
2012
Lyu, S.Y., Sunchon National University, Sunchon, Republic of Korea | Shin, A.H., Seoul Women's University, Seoul, Republic of Korea | Hahn, D.R., Laboratory of Native Korean Acanthopanacis Remedies Production Co., Cheonan, Republic of Korea | Park, W.B., Seoul Women's University, Seoul, Republic of Korea
Reactive oxygen species (ROS) are continuously produced in aerobic organisms. Overproduction of ROS is known to play a crucial role in the pathogenesis of many cardiovascular diseases, including atherosclerosis and hypertension. Superoxide dismutase (SOD) and catalase (CAT) play critical roles on the removal of excess ROS. In the present study, we investigated the antioxidant activity of cyanidins from ogapy (Acanthopanax divaricatus var. albeofructus, ADA) fruits against oxidative stress in hydrogen peroxide (H₂O₂)-pretreated U937 macrophages, and explored the plausibility of the therapeutic effect of cyanidins on atherosclerosis. As a result, H₂O₂ generation and lipid peroxidation induced by H₂O₂-pretreatment was decreased by the treatment of cyanidins in U937 macrophages. In addition, increased activity of SOD and CAT was shown in H₂O₂-pretreated cells when treated with cyanidins. Overall, the results obtained in this study showed that cyanidin 3-galactoside and cyanidin 3-lathyroside from ADA fruits could protect macrophages against the damaging effects of H₂O₂ treatment.
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