Effectiveness of Fagopyri herba feed supplementation in normal and high-fat fed rats
2012
Mišan, Aleksandra (Institute of Food Technology - FINS, Novi Sad (Serbia)) | Đurendić-Brenesel, Maja (Clinical Center Vojvodina, Novi Sad (Serbia). Institute of Forensic Medicine) | Milovanović, Ivan (Institute of Food Technology - FINS, Novi Sad (Serbia)) | Milić, Miljan (Clinical Center Vojvodina, Novi Sad (Serbia). Center of Pathology and Histology) | Pilija, Vladimir (Clinical Center Vojvodina, Novi Sad (Serbia). Institute of Forensic Medicine) | Vukmirović, Đuro (Institute of Food Technology - FINS, Novi Sad (Serbia)) | Čolović, Radmilo (Institute of Food Technology - FINS, Novi Sad (Serbia)) | Mandić, Anamarija (Institute of Food Technology - FINS, Novi Sad (Serbia)) | Lević, Jovanka (Institute of Food Technology - FINS, Novi Sad (Serbia))
Fagopyri herba has been used in the treatment of vascular diseases and reported to possess hypolipidemic effects. As a higher food intake is connected with obesity and associated cardiometabolic risk factors, the present work was undertaken to investigate the effects of Fagopyri herba consumption on body weight gain, feed intake, feed efficiency ratio and net caloric intake in male Wistar rats fed a standard and a hyperlipidemic diet for 8 weeks. For this purpose, 25 male Wistar rats were randomly divided into five groups: a standard diet group (I), a Fagopyri herba supplemented diet group (II), a high-fat diet group (III), a high-fat Fagopyri herba supplemented diet group (IV), a group eating the same diet as III group for 7 weeks and the same as group IV for 1 week (V). After 8 weeks, the feed intake was significantly lower in the three high-fat fed groups (III, IV and V) (P<0.05) than in the I and II group. The IV group had a lower body weight gain (85.80 ± 14.89 g vs. 131.60 ± 37.73 g; P<0.05) than the III group, which can be connected with its lower net caloric intake in comparison with the III group (259 kJ/100 g vs. 410 kJ/100 g). Faecal fat excretion of the V group was significantly higher than of the III group (11.800 ± 0.200% vs. 10.06 ± 0.400; P<0.05). This result suggests that the beneficial effect of Fagopyri herba in high-fat fed rats is partly mediated by higher excretion of faecal lipids. The results of this experiment suggest that Fagopyri herba consumption would be beneficial for regulation of lipid metabolism or prevention of hyperlipidemia in experimental animal models.
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