Encapsulation of Thymus serpyllum L. aqueous extract in chitosan and alginate - chitosan microbeads
2012
Trifković, Kata T. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Chemical Engineering) | Milašinović, Nikola Z.(Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Organic Chemical Technology) | Isailović, Bojana D. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Chemical Engineering) | Kalagasidis-Krušić, Melina T. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Organic Chemical Technology) | Đorđević, Verica B. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Chemical Engineering) | Knežević-Jugović, Zorica D. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Biochemical | Biotechnology), Engineering and | Bugarski, Branko M. (Faculty of Technology and Metallurgy, Belgrade (Serbia). Department of Chemical Engineering)
The aim of this study was to investigate encapsulation processes of Thymus serpyllum L. aqueous extract in chitosan and alginate-chitosan microbeads and its consecutive release. Chitosan microbeads were prepared in water-in-oil (W/O) microemulsion, while alginate-chitosan microbeads were prepared by electrostatic extrusion. The outer surface of microbeads was observed by optical microscopy. The interaction between chitosan or alginate-chitosan microbeads and extract compounds were analyzed by FT-IR. Release profiles of polyphenolic compounds from the microbeads in water was monitored. Experimental results show that the applied methods gave chitosan and alginate-chitosan microbeads with an average diameter of 390 μm and 890 μm, respectively. FT-IR analyses confirmed the presence of polyphenolic extract within the synthetized microbeads. The encapsulation efficiency was determined with respect to total polyphenolic content. Chitosan microbeads showed lower encapsulation efficiency of ~10%, but prolonged release, compared to alginate–chitosan microbeads where encapsulation efficiency was ~70%. The uniformity of the obtained microbeads was confirmed by optical microscopy. This study showed that, by some synthesis modification of both, chitosan and alginate-chitosan microbeads have the potential to be used for encapsulation of aqueous phenolic extracts.
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