Antidiabetic efficacy of Mimosa pudica (Lajwanti) root in albino rabbits
2013
Bashir, R. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Aslam, B. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Javed, I. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Muhammad, F. (University of Agriculture, Faisalabad (Pakistan). Dept. of Physiology and Pharmacology) | Zia-ud-Din, S. (University of Agriculture, Faisalabad (Pakistan). Dept. of Parasitology) | Sarfraz, M. | Fayyaz, A.
Antidiabetic effect of Lajwanti (Mimosa pudica L.) root was determined in the alloxan induced diabetic adult albino rabbits. After acclimatization, adult albino rabbits (n=6) were divided into six equal groups (I, II, III, IV, V and VI). Group I served as normal control on routine diet, group II was as untreated control on alloxan, group III was treated control on synthetic antidiabetic drug Glimepride, groups IV, V and VI were treated with three graded doses of M. pudica root powder. Diabetes was induced in all the adult albino rabbits except group I. Blood samples were drawn at 0, 5, 10, 15 and 20 days of experiment. Blood glucose was determined by the kit method. Results of group IV, V and VI shown that the glucose level decreased in diabetic rabbits at 8th and 12th hour significantly (P less than 0.05) on 10th, 15th and 20th days of the experiment. Root powder of M. pudica at dose rate of 6 mg/kg body weight significantly decreased blood glucose level in the diabetic rabbits at 12th of the sampling on day 5, 10 and 20. Therefore, it is concluded from the present study that the root powder of M. pudica has antidiabetic efficacy at a dose rate of 6 mg/kg body weight.
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