Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
2012
To Dao Cuong, Catholic University of Daegu, Gyungsan, Republic of Korea | Lim, C.J., Catholic University of Daegu, Gyungsan, Republic of Korea | Tran Thi Thu Trang, Catholic University of Daegu, Gyungsan, Republic of Korea | Bae, Y.H., Catholic University of Daegu, Gyungsan, Republic of Korea | Nguyen Van Thu, Catholic University of Daegu, Gyungsan, Republic of Korea | Nguyen The Tung, Catholic University of Daegu, Gyungsan, Republic of Korea | Tran Manh Hung, Duy Tan University, Danang city, Vietnam | Woo, M.H., Catholic University of Daegu, Gyungsan, Republic of Korea | Choi, J.S., Pukyong National University, Busan, Republic of Korea | Min, B.S., Catholic University of Daegu, Gyungsan, Republic of Korea
Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7'-(3',4'-dimethoxyphenyl)-8,8'-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7'-(3',4'-methylenedioxyphenyl)-8,8'-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-Δ∨8'-7-hydroxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (5), and (+)-erythro-(7S,8R)-Δ∨8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.
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