Diketopiperazines from Cordyceps militaris
2013
Kim, S.B., Chungbuk National University, Cheongju, Republic of Korea | Hwang, B.Y., Chungbuk National University, Cheongju, Republic of Korea | Lee, M.K., Chungbuk National University, Cheongju, Republic of Korea
In a continuation of investigation on Cordyceps militaris, thirteen compounds were isolated from the CH2Cl2 and n-BuOH-soluble fraction of C. militaris. They were identified as twelve diketopiperazines such as cyclo(L-Gly-L-Pro) (1), cyclo(L-Ala-L-Pro) (2), cyclo(L-Ser-L-Pro) (3), cyclo(L-Val-L-Pro) (4), cyclo(L-Thr-L-Pro) (5), cyclo(L-Pro-L-Pro) (6), cyclo(LThr- L-Leu) (7), cyclo(L-Tyr-L-Ala) (8), cyclo(L-Phe-L-Ser) (9), cyclo(L-Phe-L-Pro) (10), cyclo(L-Tyr-L-Pro) (11) and brevianamide F (13), and an amino acid, tryptophan (12). Their structures were identified on the basis of chemical evidences and spectroscopic analysis including 1D-NMR ( 1 H, 13 C), 2D-NMR (HSQC, HMBC) and MS spectral data. Among the isolated compounds, compounds 1, 2, 6-11 are first reported from C. militaris.
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