Effect of Polygonum multiflorum Thunberg Extract on Lipid Metabolism in Rats Fed High-Cholesterol Diet
2012
Choi, J.H., Keimyung University, Daegu, Republic of Korea | Lee, H.S., Korea Food Research Institute, Seongnam, Republic of Korea | Kim, Y.E., Korea Food Research Institute, Seongnam, Republic of Korea | Kim, B.M., Korea Food Research Institute, Seongnam, Republic of Korea | Kim, I.H., Korea Food Research Institute, Seongnam, Republic of Korea | Lee, C.H., Korea Food Research Institute, Seongnam, Republic of Korea
The principal objective of this study was to determine the effects of an ethanol extract of Polygonum multiflorumThunberg (PMT) on body lipid metabolism in rats fed a high-cholesterol diet for 5 weeks. The rats were divided into 6 groups: a control group (Ⅰ), a cholesterol-control group (Ⅱ), a control group treated with 0.5% PMT (Ⅲ), a control group treated with 1% PMT (Ⅳ), a cholesterol-control treated with 0.5% PMT (Ⅴ), and a cholesterol-control group treated with 1% PMT (Ⅵ). Body weight gains and food efficiency ratios were not significantly different among the groups. The levels of serum blood glucose and triglycerides of the treated animals significantly decreased compared to the control and the cholesterol-control groups (p less than 0.05). There was a clear tendency of decreased LDL-cholesterol level in PMT-treated animals compared to the cholesterol-control group. However, no significant differences were observed in the serum HDL- and LDL-cholesterol levels. In the ratio of HDL-cholesterol to total cholesterol and HDL-cholesterol to LDL-cholesterol concentration, both the 0.5% PMT and 1% PTM extract intake groups had a higher percentage than in the control and cholesterol-control groups (p less than 0.05). In addition, the atherosclerotic index in serum was significantly lower in the PMT intake group than those in the group control and the cholesterol-control. These results indicated that the PMT extract was effective on the improvement of lipid metabolism in SD rats.
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