Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in alpha-MSH Stimulated B16F10 Cells

Jung, H.K., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Jang, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Sim, M.O., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Lee, K.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Yeo, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Kang, B.M., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Cho, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea; Bean, C.G., Gyeongsangnamdo Agricultural Research and Extension Services, Changwon, Republic of Korea; Kim, S.C., National Institute of Horticultural and Herbal Science, RDA, Namhae, Republic of Korea; Jung, W.S., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea

Effect of Dendrobium loddigesii Rolfe Methanol Extract on Melanogenesis in alpha-MSH Stimulated B16F10 Cells

2015

Jung, H.K., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Jang, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Sim, M.O., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Lee, K.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Yeo, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Kang, B.M., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Cho, J.H., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea | Bean, C.G., Gyeongsangnamdo Agricultural Research and Extension Services, Changwon, Republic of Korea | Kim, S.C., National Institute of Horticultural and Herbal Science, RDA, Namhae, Republic of Korea | Jung, W.S., Jeollanamdo Development Institute of Traditional Korean Medicine, Jangheunggun, Republic of Korea

Dendrobium loddigesii (DL) is a valuable and versatile herbal medicine with the anecdotal claims of anti-oxidant and anti-inflammation. In the present study, we investigated the whitening effects of DL under various conditions with B16F10 melanoma cells. The DL extract inhibited melanin contents and tyrosinase activity in a dose-dependent manner, compared with untreated group. Treatment of the DL extract effectively suppressed the alpha-MSH-stimulated melanin formation, tyrosinase activity and dendrite outgrowth. Moreover, the alpha-MSH-induced mRNA expressions of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), microphthalmia-associated transcription factor (MITF) and protein expression of tyrosinase were significantly attenuated by DL treatment. These results indicate that DL may be a great cosmeceutical ingredient for its whitening effects.

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