Anti-inflammatory effect of zaluzanin C on lipopolysaccharide-stimulated murine macrophages
2016
Kang, Y.R., College of Engineering, Daegu University, Gyeongsan, Republic of Korea | Lee, H.W., College of Engineering, Daegu University, Gyeongsan, Republic of Korea | Kim, Y.H., College of Engineering, Daegu University, Gyeongsan, Republic of Korea
Zaluzanin C is a sesquiterpene lactone isolated from Ainsliaea acerifolia, a Korean medicinal plant. In the present study, the anti-inflammatory effects of zaluzanin C were demonstrated in lipopolysaccharide (LPS)-stimulated murine macrophages (RAW264.7 cells). Zaluzanin C inhibited the release of nitric oxide (NO) by alleviating the protein expression of inducible NO synthase in LPS-treated RAW264.7 cells. Furthermore, it suppressed the release of interleukin- 6 induced by LPS. Zaluzanin C was also found to block the translocation of the p65 subunit of nuclear factor-kB from the cytosol to the nucleus, which is one of the underlying mechanisms of the anti-inflammatory action of zaluzanin C. These data suggest the potential of zaluzanin C in the treatment of inflammatory diseases.
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