Integracide K: A New Tetracyclic Triterpenoid from Desmodium uncinatum (Jacq.) DC. (Fabaceae)
2017
Borice Tapondjou Tsafack, University of Dschang, Dschang, Cameroon | Beaudelaire Kemvoufo Ponou, University of Dschang, Dschang, Cameroon | Remy Bertrand Teponno, University of Dschang, Dschang, Cameroon | Raymond Ngansop Nono, University of Dschang, Dschang, Cameroon | Kristina Jenett-Siems, Freie Universitat Berlin, Berlin, Germany | Matthias F. Melzig, Freie Universitat Berlin, Berlin, Germany | Park, H.J., Sangji University, Wonju, Korea. | Leon Azefack Tapondjou, University of Dschang, Dschang, Cameroon
A new tetracyclic triterpenoid [4,4,24-trimethylcholesta-Δ8,9;14,15;24,28-trien-3β,11β,12α-triol-12-acetate, 3-sulfate] sodium salt (1), together with eight known compounds including ergosterol 5α,8α-endoperoxide (2), 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (3), 3-O-beta-D-2-acetyl-amino-2-deoxyglucopyranoxyloleanoic acid (4), hydnocarpin (5), derrone (6), isovitexin (7), erythrinin C (8), and 5,4'-dihydroxy-2''-hydroxyisopropyldihydrofurano [4,5:7,8]-isoflavone (9), were isolated from the EtOAc soluble fraction of the methanol extract of aerial part of Desmodium uncinatum collected in the western highland of Cameroon. The structures of these compounds were established by comprehensive interpretation of their spectral data mainly including 1D- (1H and 13C), 2D-NMR (1H-1H COSY, HMQC, HMBC) spectroscopic and ESI-TOF-MS mass spectrometric analysis. The isolation of an integracide-like compound from plant origin is a very unusual finding.
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