Oligochitosan as a potential anti-acne vulgaris agent: combined antibacterial effects against Propionibacterium acnes
2017
Kim, S.H., Pukyong National University, Busan, Republic of Korea | Eom, S.H., Korea Food Research Institute, Sungnam, Republic of Korea | Yu, D., University of Saskatchewan, Saskatoon, Canada | Lee, M.S., Pukyong National University, Busan, Republic of Korea | Kim, Y.M., Pukyong National University, Busan, Republic of Korea
To develop an antibacterial treatment for acne vulgaris using natural substance with few side effects, we investigated the antibacterial activities of oligochitosan against acne-related bacteria, particularly Propionibacterium acnes. Oligochitosan showed potent antibacterial effect on P. acnes. Especially, 10 kDa oligochitosan presented the highest antimicrobial effect with minimum inhibitory concentration values of 32 - 64 lg/mL on P. acnes. In addition, oligochitosan clearly reversed the antibacterial effect of tetracycline and erythromycin on P. acnes in the combination mode. The combination of tetracycline- or erythromycine-10 kDa oligochitosan resulted in a median RFIC range of 0.02 - 0.56, suggesting that the antibiotics뻩ligochitosan combination resulted in an antibacterial synergy against P. acnes. Thus, the results obtained in this research strongly supported that erythromycin and tetracycline will restore the antibacterial activity against P. acnes in the combination mode with 10 kDa oligochitosan.
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