Tyndallized Lactobacillus plantarum HY7712 Restores Whole-Body gamma-Irradiation-Impaired Th Cell Differentiation in Mice
2017
Jang, S.E., Kyung Hee University, Seoul, Republic of Korea | Ko, D.B., Kyung Hee University, Seoul, Republic of Korea | Ahn, Y.T., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Sim, J.H., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Kim, C.S., Korea Hydro & Nuclear Power Co., Ltd., Seoul, Republic of Korea | Kim, D.H., Kyung Hee University, Seoul, Republic of Korea
In the present study, we investigated the effect of tyndallized HY7712 (tHY7712) on the expression of Th cell specific transcription factors and cytokines in whole-body γ-irradiated mice. Oral administration of tHY7712 strongly recovered the γ-irradiation-suppressed expression of helper T (Th) cell- and regulatory T cell-related transcription factors and cytokines, such as T-bet, Foxp3, IFN-γ, TNF-α, and IL-10, and suppressed Th2 cell-associated transcription factor and cytokine GATA3 and IL-5, respectively. Furthermore, compared with the control, tHY7712 treatment also restored γ-irradiation-impaired natural killer and cytotoxic T cell activities against YAC-1 tumor cells to 97.8% and 98.6%, respectively.
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