Mitochondrial noncoding RNA transport
2017
Kim, K.M., National Institutes of Health, Baltimore, Maryland, USA | Noh, J.H., National Institutes of Health, Baltimore, Maryland, USA | Kotb Abdelmohsen, National Institutes of Health, Baltimore, Maryland, USA | Myriam Gorospe, National Institutes of Health, Baltimore, Maryland, USA
Mitochondria are cytosolic organelles essential for generating energy and maintaining cell homeostasis. Despite their critical function, the handful of proteins expressed by the mitochondrial genome is insufficient to maintain mitochondrial structure or activity. Accordingly, mitochondrial metabolism is fully dependent on factors encoded by the nuclear DNA, including many proteins synthesized in the cytosol and imported into mitochondria via established mechanisms. However, there is growing evidence that mammalian mitochondria can also import cytosolic noncoding RNA via poorly understood processes. Here, we summarize our knowledge of mitochondrial RNA, discuss recent progress in understanding the molecular mechanisms and functional impact of RNA import into mitochondria, and identify rising challenges and opportunities in this rapidly evolving field.
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