Five Di-caffeoylquinic Acid Derivatives and a Coumarin from the Hot-water Extract of Artemisia annua
2018
Rho, T., The Catholic University of Korea, Bucheon, Republic of Korea | Park, C., Sungkyun Biotech Co. Ltd., Suwon, Republic of Korea | Kim, S.H., Sungkyun Biotech Co. Ltd., Suwon, Republic of Korea | Yoon, K.D., The Catholic University of Korea, Bucheon, Republic of Korea
Artemisia annua L. (Compositae) is an annual herb, which has been traditionally used as an antipyretic and hemostatic agent with the herbal medicine name of Cheong Ho in Korea and China. In this study, five di-caffeoylquinic acid derivatives and a coumarin were determined from the hot-water extract of aerial parts of A. annua. The structures of isolates were elucidated to be 1,3-di-O-caffeoylqunic acid (1), 3,4-di-O-caffeoylquinic acid (2), 3,5-di-O-caffeoylqiunic acid (3), 1,5- di-O-caffeoylquinic acid (4) and 4,5-di-O-caffeoylquinic acid (5) and scopoletin (6). The presence of 1,5-di-O-caffeoylquinic acid (4) is firstly reported from A. annua in the current study.
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