Detection and characterization of avian hepatitis E virus from broiler breeders and layers in Korea
2018
Moon, H.W., Kangwon National University, Chuncheon, Republic of Korea | Sung, H.W., Kangwon National University, Chuncheon, Republic of Korea | Kwon, H.M., Kangwon National University, Chuncheon, Republic of Korea
The helicase genes and hypervariable regions (HVRs) of three avian hepatitis E viruses (HEVs) detected at three different farms were sequenced and characterized. Two isolates (DW-L and GI-B2) were classified as genotype 2 and one isolate (GR-B) was classified as genotype 1. A phylogenetic tree, based on the helicase gene and HVR nucleotide sequences, revealed the newly detected viruses and other avian HEVs were classified similarly. Unlike previously reported avian HEVs, the DW-L isolate detected in broiler breeders with characteristic lesions of avian HEV had no prolinerich motif in its HVR, suggesting that the proline-rich motif is non-essential for viral replication and infection.
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