In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7
2018
Hong, S.S., Vievisnamuh Hospital, Seoul, Republic of Korea | Lee, H.A., Wonkwang University, Iksan, Republic of Korea | Kim, J.Y., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Jeong, J.W., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Shim, J.J., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Lee, J.L., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Sim, J.H., Korea Yakult Co., Ltd., Yongin, Republic of Korea | Chung, Y., Joongbu University, Geumsan, Republic of Korea | Kim, O., Wonkwang University, Iksan, Republic of Korea
The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated the capacity of Lactobacilllus paracasei (L. paracasei) HP7, isolated from kimchi, to inhibit H. pylori growth. The effects of L. paracasei HP7 on H. pylori adhesion and H. pylori-induced inflammation were examined in AGS human gastric adenocarcinoma epithelial cells and a mouse model of H. pylori SS1 infection. L. paracasei HP7 reduced H. pylori adhesion to AGS cells and suppressed the inflammatory response in infected cells by downregulating interleukin-8. H. pylori colonization in the stomach of C57BL/6 mice was demonstrated by rapid urease test, and results showed significant decrease in mice post-treated with L. paracasei HP7. Additionally, L. paracasei HP7 decreased gastric inflammation and epithelial lesions in the stomach of H. pylori-infected mice. These results demonstrate that L. paracasei HP7 treatment can inhibit H. pylori growth and is thus a promising treatment for patients with gastric symptoms such as gastritis that are caused by H. pylori infection.
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