Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries
2019
Rhie, M.N., Ewha Womans University, Seoul, Republic of Korea | Kim, H.T., Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea | Jo, S.Y., Ewha Womans University, Seoul, Republic of Korea | Chu, L.L., Ewha Womans University, Seoul, Republic of Korea | Baritugo, K.A., Ewha Womans University, Seoul, Republic of Korea | Baylon, M.G., Ewha Womans University, Seoul, Republic of Korea | Lee, J.W., Sogang University, Seoul. Republic of Korea | Na, J.G., Sogang University, Seoul. Republic of Korea | Kim, L.H., Sogang University, Seoul. Republic of Korea | Kim, T.W., Chonnam National University, Gwangju, Republic of Korea | Park, C.H., Kwangwoon University, Seoul, Republic of Korea | Hong, S.H., University of Ulsan, Ulsan, Republic of Korea | Joo, J.C., Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea | Park, S.J., Ewha Womans University, Seoul, Republic of Korea
The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of wellknown and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of biobased chemicals.
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