The permeability of polyethylene glycol oligomers in the isolated perfused rat liver
1995
Mengelers, M.J.B.
Processes occuring in the liver are very important for the description of the kinetic behaviour of drugs and compounds present in food. Therefore this research was focussed on dispersion and distribution processes occuring in the rat liver. Polyethylene glycols were used as test compounds because they are mixtures of different oligomers and offer a set of molecules with different molecular weights and sizes. The aim was to study the influence of molecular size on the permeability of different oligomers of polyethylene glycol (PEG) in the isolated perfused rat liver. Furthermore, the feasibility of performing these studies with non-radioactive labelled PEGs was studied.
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