Synthesis of Gefitinibfrom Methyl 3-Hydroxy-4-methoxy-benzoate
Ming Dong Li | You Guang Zheng | Min Ji
This paper reports a novel synthesis of gefitinib starting from methyl3-hydroxy-4-methoxybenzoate. The process starts with alkylation of the starting material, followed by nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates andtarget molecule were characterized by 1H-NMR, 13C-NMR, MSand the purities of all these compounds were determined by HPLC. This novelsynthetic route produced overall yields as high as 37.4%.
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出版者
Molecular Diversity Preservation International
页码
p.-
其它主题
Methyl 3-hydroxy-4-methoxybenzoate; Tyrosine kinase inhibitors; Gefitinib
语言
英语
注释
Source Identifier: oai:mdpi.com:1420-3049/12/3/679/; . setSpec: Article;
类型
Journal Article
2021-02-15
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