Niobium Pentachloride Catalysed Ring Opening of Epoxides

Mauricio  Gomes Constantino; Valdemar Lacerda; Valquiria Aragão

Niobium Pentachloride Catalysed Ring Opening of Epoxides

Mauricio Gomes Constantino | Valdemar Lacerda | Valquiria Aragão

Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl5 for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested.

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