Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis
Mat Ropi Mukhtar | Ahmad Nazif Aziz | Noel F. Thomas | A. Hamid A. Hadi | Marc Litaudon | Khalijah Awang
The stem bark of Phoebe grandis afforded one new oxoproaporphine: (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (–)-8,9-dihydrolinearisine (2) is also reported. The alkaloids’ structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
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