Sera From Patients With Minimal Change Disease Increase Endothelial Permeability to Sodium
2020
Daviet, Florence | Blin, Muriel | Fallague, Karim | Bachelier, Richard | Laforêt, Manon | Carré, Manon | Poitevin, Stéphane | Dignat-George, Francoise | Blot-Chabaud, Marcel | Bardin, Nathalie | Burtey, Stéphane | Jourde-Chiche, Noémie | Leroyer, Aurélie
E dema is the main symptom of nephrotic syndrome associated to minimal change disease (MCD). Besides the increase in glomerular permeability, possibly induced by a circulating permeability factor, 1 an increase in systemic vascular permeability could participate in the constitution of edema. This study was conducted to evaluate the permeability of endothelial cells (EC) exposed to serum from nephrotic patients with MCD, to low-or high-molecularweight molecules, by trans-or paracellular transport.
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