In vitro antihyperglycaemic effects of some Malaysian plants
2011
Rohaya A. | Nik Musa’adah M. | Abdul Rashid L. | Nor Hadiani I. | Mohamad Jemain M. R.
Uncontrolled postprandial hyperglycaemia increases the risk of vascular diabetic complications. One of the therapeutic approaches to control postprandial hyperglycaemia is by inhibiting alpha-amylase and alpha-glucosidase enzyme activities. In this study, 47 extracts from 22 Malaysian tropical plants were assayed for alpha-amylase and alpha-glucosidase inhibitory activities. Four plant species demonstrated potentalpha-amylase inhibition. The plants wereBurkillantus malaccensis (stem), Horsfieldia polyspherula (leaf and stem), Labisia pumila (leaf and root) and Phyllanthus pulcher (stem). The IC 50 values of the extracts ranged from 1.2 to 2.8 μg ml-1. Four plant species could be classified as strong alpha-glucosidase inhibitors with IC50 values ranging from 2.4 to 6.1 μg ml-1. The plants were Gironniera parvifolia (stem), H. polyspherula (leaf and stem), P. pulcher (leaf and stem) and Rothmannia schoemanii (stem). Extracts of P. pulcher (stem) and H. polyspherula (leaf and stem) showed potent inhibitory activity against both enzymes. The plant extracts are potentially useful in the development of new antidiabetic remedies.
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