COVID-19 as milestone for the use of new vaccine types
2020
Marković, Milan
COVID-19 is an infectious disease caused by SARS-CoV-2 virus which belongs to the Coronaviridae group. The symptoms of the disease are primarily present in the form of respiratory syndrome similar to the symptoms of other respiratory viruses such as influenza virus but also the very common SARS-CoV-1 and MERS-CoV viruses known from the recent past. However, based on short clinical experience, it was found that apart from lungs COVID-19 affects all organ systems with unclear pathogenesis. Respiratory failure followed by systemic hypoxia and coagulation disorders is hallmarks of severe pathology. In addition, this virus belongs to the group of RNA viruses that share common characteristics with the HIV virus, which makes it very challenging for the therapy of modern medicine. There is currently controversy around the world about how to combat this epidemic. In addition to hygienic measures and measures of safe distance and isolation, there is an intense controversy about prophylactic vaccines. In this review article, the insight into all aspects of vaccination and methods for their design based on technological tools possessed by modern science with special reference to genetic (DNA, RNA) vaccines is provided, and the question arises of whether there is a justification of novel technology urgent application in the event of a COVID-19 pandemic.
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