Rangelia vitalii: changes in the enzymes ALT, CK and AST during the acute phase of experimental infection in dogs
2012
Costa, Márcio Machado(Federal University of Santa Maria Department of Small Animals) | França, Raqueli Teresinha(Federal University of Santa Maria Department of Small Animals) | Da Silva, Aleksandro Schafer(Federal University of Santa Maria Department of Microbiology) | Paim, Carlos Breno(Federal University of Santa Maria Department of Small Animals) | Paim, Francine(Federal University of Santa Maria Department of Small Animals) | Amaral, Carlos Henrique do(Federal University of Paraná Department of Veterinary Medicine) | Dornelles, Guilherme Lopes(Federal University of Santa Maria Department of Small Animals) | Cunha, João Paulo Monteiro Carvalho Mori da(Federal University of Santa Maria Department of Small Animals) | Soares, João Fabio(University of São Paulo Department of Preventive Veterinary Medicine and Animal Health) | Labruna, Marcelo Bahia(University of São Paulo Department of Preventive Veterinary Medicine and Animal Health) | Mazzanti, Cinthia Melazzo Andrade(Federal University of Santa Maria Department of Small Animals) | Monteiro, Silvia Gonzalez(Federal University of Santa Maria Department of Microbiology) | Lopes, Sonia Terezinha dos Anjos(Federal University of Santa Maria Department of Small Animals)
英语. Rangelia vitalii is a protozoon that causes diseases in dogs, and anemia is the most common laboratory finding. However, few studies on the biochemical changes in dogs infected with this protozoon exist. Thus, this study aimed to investigate the biochemical changes in dogs experimentally infected with R. vitalii, during the acute phase of the infection. For this study, 12 female dogs (aged 6-12 months and weighing between 4 and 7 kg) were used, divided in two groups. Group A was composed of healthy dogs (n = 5); and group B consisted of infected animals (n = 7). Blood samples were collected on days 0, 10, 20 and 30 after infection, using tubes without anticoagulant to obtain serum and analyze the biochemical parameters. An increase in alanine aminotransferase (ALT) on day 20 (P < 0.05) was observed. Also, increased creatine kinase (CK) and aspartate aminotransferase (AST) levels were observed throughout the experimental period (P < 0.05). No changes in the serum gamma-glutamyltransferase, urea and creatinine levels were observed. Thus, is possible to conclude that experimental infection with R. vitalii in dogs causes changes to the biochemical profile, with increased ALT, AST and CK enzyme levels.
显示更多 [+] 显示较少 [-]葡萄牙语. Rangelia vitalii é um protozoário que causa doença em cães, sendo a anemia o achado laboratorial mais frequente. No entanto, existem poucos estudos sobre as alterações bioquímicas em cães infectados com o protozoário. Assim, este estudo tem como objetivo investigar as alterações bioquímicas de cães experimentalmente infectados com R. vitalii na fase aguda da infecção. Para o estudo, foram utilizados 12 cães fêmeas (com idade entre 6 a 12 meses e peso entre 4 a 7 kg), divididos em dois grupos. O grupo A (n = 5) foi composto de animais saudáveis e o grupo B (n = 7) de animais infectados. Amostras de sangue foram coletadas nos dias zero, dez, vinte e trinta PI, utilizando tubos sem anticoagulante para obtenção de soro e análise dos parâmetros bioquímicos. Foi observado um aumento na alanino aminotransferase (ALT) no dia 20 PI (P < 0,05) e aumento na creatinoquinase (CK) e aspartato aminotransferase (AST) em todo o período experimental (P < 0,05). Não foram observadas alterações séricas na gama-glutamiltransferase, uréia e creatinina. Portanto, é possível concluir que a infecção experimental por R. vitalii causa alterações no perfil bioquímico, com aumento na ALT, CK e AST.
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