Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas
Yi-Lin He; Pei-Zhi Huang; Hong-Ying Yang; Wei-Jiao Feng; Zhao-Cai Li; Kun Gao
Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 &mu:M.
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