NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases
2020
Ángel Cores | Marta Piquero | Mercedes Villacampa | Rafael León | J. Carlos Menéndez
NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.
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书目信息
出版者
MDPI AG
其它主题
Nrf2 regulation; Neurodegenerative diseases; Keap1; Nrf2–are pathway
语言
英语
类型
Journal Article
来源
Biomolecules, Vol 10, Iss 904, p 904 (2020)
2022-09-15
AGRIS AP