Mechanisms of Transforming DNA Uptake to the Periplasm of Bacillus subtilis

Jeanette Hahn; Micaela DeSantis; David Dubnau

Mechanisms of Transforming DNA Uptake to the Periplasm of Bacillus subtilis

2021

Jeanette Hahn | Micaela DeSantis | David Dubnau

Transformation is a widely distributed mechanism of bacterial horizontal gene transfer that plays a role in the spread of antibiotic resistance and virulence genes and more generally in evolution. Although transformation was discovered nearly a century ago and most, if not all the proteins required have been identified in several bacterial species, much remains poorly understood about the molecular mechanism of DNA uptake.

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