Therapeutic effectiveness of Ocimum basilicum extract on bovine cutaneous papillomatosis
2020
AbdulRahman A. Saied | Ashraf A. El-Ghoneimy | Abdel-latif Seddek | Sary Kh. AbdelGhafar | Samy A.F. Morad
Bovine cutaneous papillomatosis is a common cutaneous disease of cattle in the Egyptian veterinaryfield. Ocimum basilicum L. (Rehan) is one of the aromatic plants originating in Asia and Africa. Manystudies showed that Ocimum basilicum has interesting antiviral and anticancer activities. However, thereis no report demonstrating the clinical significance of the anti-papilloma activity of Ocimum basilicumagainst bovine skin papillomas. Thus, our study was designed to evaluate the therapeutic potential ofOcimum basilicum extract (OBEx) as an anti-papilloma agent against bovine papillomatosis. OBEx wasprepared and undergone phytochemical analysis that revealed presence of alkaloids, phenolics, andflavonoids. Ten cutaneous papillomatosis-infected cattle were diagnosed clinically andhistopathologically. Animals were treated with OBEx ointment 2% that topically applied daily andpapillomas regression was recorded weekly. Clinically, papillomas started to disappear from the 7th- 21stday after the start of treatment. Histopathological analysis showed improvement in histological features ofwart tissue returning to the normal skin structure with presence of lymphocytic infiltration. We concludedthat the topical application of OBEx is an effective, promising alternative, cheap, and easily apply agentfor treatment of skin papilloma.
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