Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model

Gordana D. Vitaliano; Jae K. Kim; Marc J. Kaufman; Christopher W. Adam; Gonzalo Zeballos; Abinaya Shanmugavadivu; Sivan Subburaju; Jay P. McLaughlin; Scott E. Lukas; Franco Vitaliano

Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model

2022

Vitaliano et al. show in mice that engineered clathrin triskelia (CT) conjugated to BDNF (BDNF-CT) and delivered intranasally increases hippocampal BDNF concentrations 400-fold above that achieved previously with intranasal BDNF alone. They also show that it enhance neurogenesis, synaptogenesis and cognition in a mouse model of HIV/neuroAIDS, highlighting its potential in regenerative medicine.

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