Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

Le Thi My Le; James Robert Thompson; Phuoc Xuan Dang; Janarjan Bhandari; Amer Alam

Structures of the human peroxisomal fatty acid transporter ABCD1 in a lipid environment

2022

Le Thi My Le | James Robert Thompson | Phuoc Xuan Dang | Janarjan Bhandari | Amer Alam

Le et al. present cryo-EM structures of the peroxisomal very long chain fatty acid (VLCFA) transporter ABCD1 in phospholipid nanodiscs in a nucleotide-bound conformation open to the peroximsomal lumen and a conformation open to the cytosol. These structures provide the basis for structure-function studies to investigate VLCFA transport properties, disease-causing mutations, and drug design for disorders, such as X-linked adrenoleukodystrophy, associated with ABCD1 dysfunction.

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