SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

Meng-Li Wu; Feng-Liang Liu; Jing Sun; Xin Li; Xiao-Yan He; Hong-Yi Zheng; Yan-Heng Zhou; Qihong Yan; Ling Chen; Guo-Ying Yu; Junbiao Chang; Xia Jin; Jincun Zhao; Xin-Wen Chen; Yong-Tang Zheng; Jian-Hua Wang

SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury

2021

A schematic illustration of SARS-CoV-2 triggers MC rapid degranulation to induce alveolar epithelial inflammation and lung injury. SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.

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