Effect of serial in vivo passages on the adaptation of H1N1 avian influenza virus to pigs

Urbaniak Kinga; Kowalczyk Andrzej; Pomorska-Mól Małgorzata; Kwit Krzysztof; Markowska-Daniel Iwona

Effect of serial in vivo passages on the adaptation of H1N1 avian influenza virus to pigs

2022

Urbaniak Kinga | Kowalczyk Andrzej | Pomorska-Mól Małgorzata | Kwit Krzysztof | Markowska-Daniel Iwona

The lack of proofreading activity of the viral polymerase and the segmented nature of the influenza A virus (IAV) genome are responsible for the genetic diversity of IAVs and for their ability to adapt to a new host. We tried to adapt avian IAV (avIAV) to the pig by serial passages in vivo and assessed the occurrence of point mutations and their influence on viral fitness in the pig’s body.

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