A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA

Vincent V. Pham; Michael Gao; Jennifer L. Meagher; Janet L. Smith; Victoria M. D’Souza

A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA

2022

Vincent V. Pham | Michael Gao | Jennifer L. Meagher | Janet L. Smith | Victoria M. D’Souza

Here the structure of the HEXIM arginine rich motif in complex with the stemloop-1 of 7SK snRNA is determined, and insights are provided into how the HIV protein Tat overcomes the structural constraints required to displace HEXIM, an event required for the extraction of pTEFb during transcriptional elongation.

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